Faucher Lab
Faucher Lab
Genetics of water-borne bacterial pathogens
Publications
Publications
Faucher SP*, Matthews S, Nickzad A, Vounba P, Shetty D, Bédard E, Prévost M, Déziel E, Paranjape K. (2021) Toxoflavin secreted by Pseudomonas alcaliphila inhibits growth of Legionella pneumophila and its host Vermamoeba vermiformis. Available on BioRxiv.
Saad M, Castiello, FR, Faucher SP*, Tabrizian M. (2022) Introducing an SPRi-based titration assay using aptamers for the detection of Legionella pneumophila. Sensors and Actuators B: Chemical, 351: 130933.
Saad M, Faucher SP*. (2021) Aptamers and Aptamer-Coupled Biosensors to Detect Water-Borne Pathogens. Frontiers in Microbiology, 12: 643797.
Bédard E, Trigui H, Liang J, Doberva M, Paranjape K, Lalancette C, Allegra S, Faucher SP*, Prévost M. (2021) Local adaptation of Legionella pneumophila within a hospital hot water system increases tolerance to copper. Applied Environmental Microbiology, 87(10): e00242-21. Available on BioRxiv.
Saoud J, Mani T, Faucher SP*. (2021) The Tail-specific protease is important for Legionella pneumophila to survive thermal stress in water and inside amoeba. Applied Environmental Microbiology, 87(9): e02975-20. Available on BioRxiv.
Darvishzadeh P, Orsat V, Faucher SP. (2021) Encapsulation of Russian Olive Water Kefir as an Innovative Functional Drink with High Antioxidant Activity. Plant Foods for Human Nutrition.
Saoud J, Carrier MC, Massé E, Faucher SP*. (2020) The small regulatory RNA Lpr10 regulates the expression of RpoS in Legionella pneumophila. Molecular Microbiolgy,115(4): 789-806.
Paranjape K, Bédard E, Shetty D, Hu M, Choon FCP, Prévost M, Faucher SP. (2020) Unravelling the Importance of the Eukaryotic and Bacterial Communities and their Relationship with Legionella spp. Ecology in Cooling Towers: A Complex Network. Microbiome, 8: 157.
Saad M, Chinerman D, Tabrizian M, Faucher SP. (2020) Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity. Scientific Reports, 10: 9145.
Paranjape K, Bédard E, Whyte L, Ronholm J, Prévost M, Faucher SP. (2020) Presence of Legionella spp. in cooling towers: the role of microbial diversity, Pseudomonas, and continuous chlorine application. Water Research, 169:115252. Available on BioRxiv, doi: 10.1101/540302.
Paniagua AT, Paranjape K, Hu M, Bédard E, Faucher SP. (2019) Impact of temperature on Legionella pneumophila, its protozoan host cells, and the microbial diversity of the biofilm community of a pilot cooling tower. Science of the Total Environment, 712: 136131. Available on BioRxiv, doi: 10.1101/2019.12.12.874149.
Lalancette C, Leduc JM, Malo J, Fournier E, Saoud J, Faucher SP, Pacheco AL, Bernard K, Martineau C, Lévesque S. Legionella quinlivanii strain isolated from human: case report and whole genome sequencing analysis. Journal of the Association of Medical Microbiology and Infectious Disease, in press.
Braun RS, Mendis N, Li L, Faucher SP. (2019) Quantification of viable but non-culturable cells of Legionella pneumophila. Methods in Molecular Biology, 1921: 45-53
Bédard E, Paranjape K, Lalancette C, Villion M, Quach C, Laferrière C, Faucher SP, Prévost M. (2019) Legionella pneumophila levels and sequence-type distribution in hospital hot water samples from faucets to connecting pipes.Water Research, 156:277.
Giannakopoulou N, Mendis N, Zhu L, Gruenheid S, Faucher SP, Le Moual H. (2018) The Virulence Effect of CpxRA in Citrobacter rodentium Is Independent of the Auxiliary Proteins NlpE and CpxP. Frontiers in Cellular and Infection Microbiology, 8: 320.
Mendis N,Saad M, Tsang A, Faucher SP. (2018) Deletion of oxyRin Legionella pneumophila causes growth defect on agar.Canadian Journal of Microbiology, 64: 1030.
Mendis N, McBride P, Saoud J, Mani T, Faucher SP. (2018) The LetA/S two-component system regulates transcriptomic changes that are essential for the survival of Legionella pneumophila in water. Scientific Reports, 8: 8764.
Trigui H, Lee K, Thibodeau A, Lévesque S, Mendis N, Fravalo P, Letellier A, Faucher SP. (2017) Phenotypic and transcriptomic responses of Campylobacter jejuni suspended in an artificial freshwater medium. Frontiers in Microbiology, 8: 1203.
Melaine F, Saad M, Faucher SP, Tabrizian M. (2017) Selective and High Dynamic Range Assay Format for Multiplex Detection of Pathogenic Pseudomonas aeruginosa, Salmonella typhimurium, and Legionella pneumophila RNAs Using Surface Plasmon Resonance Imaging. Analytical Chemistry, 89: 7802.
Li L, Faucher SP. (2017) Role of the luxR-family transcriptional regulator Lpg2524 in the survival of Legionella pneumophila in water. Canadian Journal of Microbiology, 63: 535.
Li L, Faucher SP. (2016) The membrane protein LasM promotes the cultivability of Legionella pneumphila in water. Frontiers in Cellular and Infection Microbiology, 6: 113.
Bédard E, Lévesque S, Martin P, Pinsonneault L, Paranjape K, Lalancette C, Dolcé CE, Villion M, Valiquette L, Faucher SP, Prévost M. (2016) Energy conservation promotes Legionella pneumophila growth: the probable role of heat exchangers in a nosocomial outbreak. Infection Control & Hospital Epidemiology, 37: 1475.
Tanner J, Li L, Faucher SP, Brassinga AK. (2016) The CpxRA two-component system contributes to Legionella pneumophilavirulence. Molecular Microbiology, 100: 1017
Trigui H, Paquet VE, Charette SJ, Faucher SP. (2016) Packaging of Campylobacter jejuni into multilamellar bodies by the ciliate Tetrahymena pyriformis. Applied Environmental Microbiology, 82: 2783.
Trigui H, Thibodeau A, Fravalo P, Letellier A, Faucher SP. (2015) Survival in water of Campylobacter jejuni strains isolated from the slaughterhouse. SpringerPlus, 4:799.
Mendis N, McBride P, Faucher SP. (2015) Short-term and long-term survival, and virulence of Legionella pneumophila in the defined freshwater medium Fraquil. PLoS One, 10: e0139277.
Li L, Mendis N, Trigu H, Faucher SP. (2015) Transcriptomic changes of Legionella pneumophila in water. BMC Genomics, 16: 637.
Foudeh AM, Trigui H, Mendis N, Faucher SP, Veres T, Tabrizian M. (2015) Rapid and Specific SPRi Detection of L. pneumophila in Complex Environmental Water Samples. Analytical and Bioanalytical Chemistry, 407: 5541.
Faucher SP, Charette SJ. (2015) Editorial on bacterial pathogens in the non-clinical environment. Frontier Microbiology, 6: 331.
Torre S, Faucher SP, Fodil-Cornu N, Bongfen S, Berghout J, Schwatzentruber J, Majewski J, Lathrop M, Cooper A, Vidal S, Gros P. (2015) THEMIS is Required for Pathogenesis of Cerebral Malaria and for Protection Against Pulmonary Tuberculosis. Infection and Immunity, 83: 759.
Trigui H, Dudyk P, Oh J, Hong JI, Faucher SP. (2015) A regulatory feedback loop between RpoS and SpoT supports the survival of Legionella pneumophila in water. Applied Environmental Microbiology, 81: 918.
Mendis N, Lin YR, Faucher SP. (2014) Comparison of virulence properties of Pseudomonas aeruginosa exposed to water and grown in rich broth. Canadian Journal of Microbiology, 60: 777.
Lévesque S, Plante PL, Mendis N, Cantin P, Marchand G, Charest H, Raymond F, Huot C, Goupil-Sormany I, Desbiens F, Faucher SP, Corbeil J, Tremblay C. (2014) Genomic characterization of a large outbreak of Legionella pneumophila serogroup 1 strains in Québec City, 2012. Plos ONE, 9: e103852.
Li L, Mendis N, Trigui H, Oliver JD, Faucher SP (2014) The importance of the viable but non-culturable state in bacterial pathogens. Frontiers Microbiology, 5: 258.
Foudeh AM, Daoud JT, Faucher SP, Veres T, Tabrizian M. (2013) Sub-femtomole Detection of 16s rRNA from Legionella pneumophila Using Surface Plasmon Resonance Imaging. Biosensors and Bioelectronics, 52: 129-135.
Trigui H, Mendis, N, Laam Li, Saad M, Faucher SP. (2013) Facets of small RNA-mediated regulation in Legionella pneumophila. Current Topics in Microbiology and Immunology, 376: 53-80.
Trigui H, Dudyk P, Sum J, Shuman HA, Faucher SP. (2013) Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element. Microbiology, 159: 1649-1660.
Lu J, Struewing I, Buse H, Kou J, Shuman H, Faucher SP, Ashbolt N. (2013) Legionella pneumophila Transcriptional Response Following Exposure to CuO Nanoparticles. Applied and Environmental Microbiology, 79: 2713-2720.
Faucher SP, Shuman, HA. (2013) Methods to study Legionella transcriptome in vitro and in vivo. Methods in molecular biology, 954: 567-582.
Fortier A, Faucher SP, Diallo K, Gros P. (2011) Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages. Immunobiology, 216: 1274-1285.
Faucher SP, Shuman HA. (2011) Small regulatory RNA and Legionella pneumophila. Frontiers in microbiology, 2: 1-14.
Faucher SP, Mueller C, Shuman HA. (2011). Legionella pneumophila transcriptome during intracellular multiplication in human macrophages. Frontiers in microbiology. 2: 60.
Anderson OR, Wang W, Faucher SP, Bi K, Shuman HA. (2011) A New Heterolobosean Amoeba Solumitrus palustris n. gen., n. sp. Isolated from Freshwater Marsh Soil. Journal of Eukaryotic Microbiology, 58: 60-67.
Faucher SP, Fiedlander G, Livny, J Margalit H, Shuman HA. (2010) Legionella pneumophila 6S RNA optimizes intracellular multiplication. PNAS. 107: 7533-7538.
Hovel-Miner G, Faucher SP, Shuman HA. (2010) ArgR regulated genes are derepressed in the Legionella-containing vacuole. Journal of bacteriology. 192: 4504-4516.
Hovel-Miner G, Pampou S, Faucher SP, Clarke M, Morozova I, Morozov P, Russo JJ, Shuman HA, Kalachikov S. (2009) ?S controls multiple pathways associated with intracellular multiplication of Legionella pneumophila. Journal of Bacteriology. 191: 2461-2473.
Faucher SP, Forest C, Béland M, Daigle F. (2009) A novel PhoP-regulated locus encoding the cytolysin ClyA and the secreted invasin TaiA of Salmonella enterica serovar Typhi is involved in virulence. Microbiology. 155(Pt 2): 477-488.
Charpentier X, Faucher SP, Kalachikov S, Shuman HA. (2008) Loss of RNase R induces competence development in Legionellapneumophila. Journal of Bacteriology. 190: 8126-8136.
Poirier K, Faucher SP, Béland M, Brousseau R, Gannon V, Martin C, Harel J, Daigle F. (2008) Escherichia coli O157:H7 survives within human macrophages: global gene expression profile and involvement of the Shiga toxins. Infection and Immunity. 76: 4814-4822.
Faucher SP, Viau C, Gros PP, Daigle F, Le Moual H. (2008) The prpZ gene cluster encoding eukaryotic-type Ser/Thr protein kinases and phosphatases is repressed by oxidative stress and involved in Salmonella enterica serovar Typhi survival in human macrophages. FEMS Microbiology Letters. 281:160-166
Forest C, Faucher SP, Poirier K, Houle S, Dozois CM, Daigle F. (2007) Contribution of the stg fimbrial operon of Salmonella enterica serovar Typhi during interaction with human cells. Infection and Immunity. 75: 5264-5271
Faucher SP, Porwollik S, Dozois CM, McClelland M, Daigle F. (2006) Transcriptome of Salmonella enterica serovar Typhi within macrophages revealed through the selective capture of transcribed sequences. PNAS. 113: 1906-1911.
Faucher SP, Curtiss III R, Daigle F. (2005) Selective Capture of Salmonella enterica Serovar Typhi Genes Expressed in Macrophages that are absent from Salmonella enterica Serovar Typhimurium Genome. Infection and Immunity. 73: 5217-5221.
Abromaitis S, Faucher S, Béland M, Curtiss III R, Daigle F. (2005) The presence of the tet gene from cloning vector impairs Salmonella survival in macrophages. FEMS Microbiology Letters. 242: 305-312
Quotes
There is no sin in being ignorant; the sin is to remain ignorant.
Roy Curtiss III
In the fields of observation, chance favors only the prepared mind.
Louis Pasteur
I believe in evidence. I believe in observation, measurement, and reasoning, confirmed by independent observers. I'll believe anything, no matter how wild and ridiculous, if there is evidence for it. The wilder and more ridiculous something is, however, the firmer and more solid the evidence will have to be.
Isaac Asimov
Contact
Sebastien P. Faucher
Associate Professor
Department of Natural Resource Sciences
21,111 Lakeshore Rd.
Ste. Anne de Bellevue, QC
H9X 3V9
Tel: 514-398-7886
sebastien.faucher2@mcgill.ca
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